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Marching Powder

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In a study of cocaine users, the average time taken to reach peak subjective effects was 14.6minutes. [52] Any damage to the inside of the nose is due to cocaine constricting blood vessels — and therefore restricting blood and oxygen/nutrient flow — to that area.

a b Humphrey AJ, O'Hagan D (October 2001). "Tropane alkaloid biosynthesis. A century-old problem unresolved". Natural Product Reports. 18 (5): 494–502. doi: 10.1039/b001713m. PMID 11699882. Tallarida CS, Egan E, Alejo GD, Raffa R, Tallarida RJ, Rawls SM (April 2014). "Levamisole and cocaine synergism: a prevalent adulterant enhances cocaine's action in vivo". Neuropharmacology. 79: 590–5. doi: 10.1016/j.neuropharm.2014.01.002. PMC 3989204. PMID 24440755.DrugFacts: Cocaine". National Institute on Drug Abuse. April 2013. Archived from the original on 11 July 2015 . Retrieved 11 July 2015. Nutt DJ, King LA, Phillips LD (November 2010). "Drug harms in the UK: a multicriteria decision analysis". Lancet. 376 (9752): 1558–65. CiteSeerX 10.1.1.690.1283. doi: 10.1016/S0140-6736(10)61462-6. PMID 21036393. S2CID 5667719. Despite the legislation authorities remained relaxed about its use and prosecutions were rare. It was recognised for its ability to stave off fatigue and became increasingly popular among students and the music industry.

Treatment with contingency management, such as providing vouchers for retail items contingent upon objectively-verified abstinence from recent drug use, has been shown in randomized clinical trials to significantly reduce the likelihood of having a positive test for the presence of cocaine. [156] Vaccine Cocaine crosses the blood–brain barrier via both a proton-coupled organic cation antiporter [19] [20] and (to a lesser extent) via passive diffusion across cell membranes. [21] As of September 2022, the gene or genes encoding the human proton-organic cation antiporter had not been identified. [101]In 1879, Vassili von Anrep, of the University of Würzburg, devised an experiment to demonstrate the analgesic properties of the newly discovered alkaloid. He prepared two separate jars, one containing a cocaine-salt solution, with the other containing merely saltwater. He then submerged a frog's legs into the two jars, one leg in the treatment and one in the control solution, and proceeded to stimulate the legs in several different ways. The leg that had been immersed in the cocaine solution reacted very differently from the leg that had been immersed in saltwater. [169]

Embury-Dennis T. "It's legal to manufacture cocaine and heroin for medical use — and Britain is the world's biggest exporter". Business Insider.

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Sigma receptors are affected by cocaine, as cocaine functions as a sigma ligand agonist. [110] Further specific receptors it has been demonstrated to function on are NMDA and the D 1 dopamine receptor. [111] World Health Organization (2007). International medical guide for ships. World Health Organization. p.242. ISBN 978-9241547208. Archived from the original on 30 April 2016. Cocaine use is prevalent across all socioeconomic strata, including age, demographics, economic, social, political, religious, and livelihood. [186]

Casciani D (4 June 2015). "Cocaine in sewage: London tops league table". BBC News. Archived from the original on 4 June 2015 . Retrieved 4 June 2015.Martin RT (October 1970). "The role of coca in the history, religion, and medicine of South American Indians". Economic Botany. 24 (4): 422–438. doi: 10.1007/BF02860746. S2CID 34523519.

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