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Probiotic 6 Billion Multi-Strain Live Bio Cultures Complex with Prebiotic, 60 Vegetarian Capsules. 100 Billion CFU Source Powder.

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A study in people with Salmonella infection suggested that the effects of taking Lactobacillus plantarum varied according to sex. Although the study authors saw little evidence that this probiotic may treat Salmonella, they noted how males and females experienced the symptoms and clearance of the infection differently.

Meet the Experts: Roshini Rajapaksa, M.D., a gastroenterologist with NYU Langone Health; Frances Largeman-Roth, R.D.N., a New York City-based nutrition expert.

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Borgeraas H, et al . (2018). Effects of probiotics on body weight, body mass index, fat mass and fat percentage in subjects with overweight or obesity: A systematic review and meta-analysis of randomized controlled trials. https://internationalprobiotics.org/probiotic-modulation-of-the-microbiota-gut-brain-axis-a-role-for-gender-and-age/ Ferrarese R, et al. (2018). Probiotics, prebiotics and synbiotics for weight loss and metabolic syndrome in the microbiome era. The effectiveness of probiotics depends on a person’s unique gut microbiome, lifestyle factors, and the CFU and strains of bacteria in the supplement.

People can do their research into which specific strains might work for their particular condition. A healthcare professional can help with this. It contains over 8 billion CFU from 12 bacteria strains, including Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus paracasei, Lactobacillus gasseri, Lactobacillus rhamnosus, and Lactobacillus acidophilus. Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal diseases and is characterized by recurrent abdominal pain associated with changes in stool frequency and form, with no recognized underlying pathological or organic etiology [ 1]. The incidence of IBS varies significantly between countries and regions [ 2]. A meta-analysis published in 2012 revealed that a pooled estimate of international IBS prevalence was 11.2% [ 3]. As there are no specific biomarkers for IBS and the disease is diagnosed clinically based on the Rome criteria, epidemiological data may depend on the criteria used [ 4]. A recent epidemiological survey using the Rome IV criteria revealed that the prevalence of IBS in the general population globally is 4.1% in comparison with 10.1% when the Rome III criteria were used [ 5]. Depending on the predominant alteration in bowel habits, IBS can be classified into diarrhea-predominant IBS (IBS-D), constipation-predominant IBS, and IBS with mixed bowel habits, and IBS-D accounts for about one-third of all IBS cases but with more severe outcomes [ 2]. Szajewska H. Pooling data on different probiotics is not appropriate to assess the efficacy of probiotics. Eur J Pediatr. 2014;173:975.Recently, there is a rising concern over the high prevalence and spread of antimicrobial-resistant (AMR) pathogens worldwide. This global challenge is multifactorial and linked to selective pressure due to the frequent, prolonged, and irrational use of antibiotics in humans and animals [ 97]. The prolonged antimicrobial intake depletes the gut microbial populations thereby allowing the proliferation of pathogenic AMR pathogens like toxigenic Clostridium difficile, extended-spectrum β-lactamase (ESBL) producing Enterobacteria, methicillin-resistant S. aureus (MRSA), vancomycin-resistant Enterococcus species and other multi-drug resistant bacteria [ 98]. Patients on prolonged treatment with broad-spectrum antibiotics are at high risk of antibiotics-associated diarrhea and pseudomembranous colitis caused by antibiotic-resistant C. difficile and other pathogenic bacteria [ 99, 100]. Some probiotics’ ability to modulate the intestinal microbiome is one of the mechanisms by which they prevent antibiotics-associated diarrhea and decrease the spread of AMR bacteria [ 101]. Lakhtin, et al. [ 102] reported that multi-strain probiotics consisting of L. acidophilus (strains NK1, K3III24, 100 ash), Bifidobacterium adolescentis MC 42, B. bifidum, and B. gallinarum GB synergistically produced lectins with antimicrobial activity against clinical strains of nystatin-resistant Candida albicans, S. aureus, and their biofilms. Experimental administration of probiotics to mice showed the inhibition of C. difficile by a multi-strain probiotic containing four strains of E. faecalis [ 103] ( Table 1). Very similar work by Kondepudi, et al. [ 99] also showed the inhibition of C. difficile by the administration of multi-strain probiotics containing L. plantarum F44, L. paracasei F8, B. breve 46, and B. lactis to mice experimentally infected with C. difficile. The minimal side effects associated with the intake of probiotics for treatment coupled with the high incidence of reoccurrence of infections such as UTI [ 104] is also increasing the use of probiotics as a suitable alternative or adjunct therapeutic plan to conventional antimicrobials [ 33]. Probiotics do not leave residues or facilitate the development of resistance to antibiotics because they are preparations of live organisms [ 105]. https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/effect-of-lactobacillus-rhamnosus-cgmcc13724-supplementation-on-weight-loss-and-maintenance-in-obese-men-and-women/7C9810D79528C4ADC77A22EE45F9CA8E/core-reader Probiotics can help populate the gut with good bacteria. This is a key part of a person’s immune system. Gut bacteria have many bodily functions and affect things such as weight, mood, and inflammation. Products often contain Lactobacillus or Bifidobacterium species, although many other species exist. According to some research, different strains of the same species of probiotics can act in different ways.

https://gastro.org/press-releases/aga-does-not-recommend-the-use-of-probiotics-for-most-digestive-conditions/ If you’re after a simple all-rounder, that’s affordable, effective, user-friendly and free from any unwanted ingredients, look no further than NOW Probiotic-10™ 25 Billion Veg Capsules. Synbiotic B: L. acidophilus, L. casei, L. salivarius, L. plantarum, L. rhamnosus, L. brevis, B. bifidum, B. lactis, S. thermophilus, prebiotic inulin (chicory root extract), protease, amylase, cellulase, hemicellulase, lipase, papain and bromelain L. acidophilus NCIMB 30184, L. fermentum NCIMB 30226, L. plantarum NCIMB 30187, and L. rhamnosus NCIMB 30188

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decreased the incidence of cesarean section rate and newborn’s hyperbilirubinemia and hospitalization

Improvement of endothelial barrier, inhibition of mast cell, activation of proinflammatory cytokines, and decrease endotoxin The bacteria in a person’s gut may connect with their weight. A small 2019 study found that people following a low calorie diet for 15 weeks experienced changes in their gut bacteria. They also had a reduction in bacteria associated with atherosclerosis, which occurs when the arteries become clogged with plaque. For conditions such as Crohn’s disease, ulcerative colitis, IBS, and acute infectious gastroenteritis, probiotics are only recommended in the context of a clinical trial. The company’s products are manufactured in Current Good Manufacturing Practices (cGMP) certified facilities to ensure purity, strength, and ingredient composition. Dimidi E, et al. (2014). The effect of probiotics on functional constipation in adults: A systematic review and meta-analysis of randomized controlled trials.

Vaginal probiotics encourage a healthy vaginal microbiome

The manufacturer states the ingredients have been clinically studied for their effect on weight management. The study found that participants regularly taking the probiotics experienced a 5% average reduction in visceral and subcutaneous body fat. Inulin is a starchy substance found in a wide variety of fruits & vegetables. Our inulin is sourced from chicory root, making it a great natural source of fiber. Several studies suggest using multi-strains probiotics to prevent and treat different kinds of conditions from non-infectious to infectious diseases. Most of these studies emphasized probiotics in diets and have shown several derived benefits from such administrations. The potential of individual probiotic organisms to act in synergy or additively when in a mixture, holds a grand promise for future use in treating various diseases. Based on this review, probiotic organisms could secrete various substances that can inhibit the multiplication of pathogenic microbes, which is vital for future considerations because of the safety in its consumption and the associated health benefits. The current global challenges associated with the rise and spread of antimicrobial resistance by several pathogens had provoked the need for suitable alternatives to the current antibiotics, thus, indicating the need for further development of probiotics because of its potential in producing several bioactive compounds like lectins, bacteriocins, bioactive proteins, and antibacterial peptides that are inhibitory to pathogenic antibiotic-resistant bacteria and some fungi. The production of these essential bioactive peptides could be harnessed for further development into bio-additives to be used instead of the whole-cell probiotics formulations. In animals, feed supplementation with probiotics has proven helpful by improving growth performance and weight gain, meat quality, and humoral immunity and decreasing pathogenic microbes’ shedding. The use of probiotics could gradually outshine the prophylactic applications of antimicrobial drugs for growth enhancement in animals, thereby decreasing the spread of antimicrobial-resistant pathogens. Furthermore, this review had also shown that probiotics could be used in combination with prebiotics as symbiotics to give maximum benefits for better physiological effects. Therapeutic use of probiotics in a mixture with other compounds such as zinc and some antimycotic agents could exert more effects compared to the usage of those substances alone. There are clearly pros and cons for both singleand multi-strain probiotics – the former being more stable, the latter havingthe potential to offer more benefits, dependent on the strains used and condition being targeted.

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